riociguat data on file, May 2009 World Health Organization click here to see more . Chronic respiratory diseases: Pulmonary Hypertension. Link here. S. Rosenkranz. Pulmonary Hypertension: Current Diagnosis and Treatment. Cardiol. 96:527-541 Oleg V. Evgenov, Pacher P l, Peter M. Schmidt, Gy rgy Hask, Harald HHW Schmidt, Johannes-Peter Stasch? NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and Therapeutic Potential. Nature Reviews Drug Discovery. September 2006, from 755 to 769th.

Riociguat resulted in clinically relevant improvements in walking distance from baseline in the 6 – MWT evident evident as early as 14 days after initiation of treatment. Significant improvements in PAH and CTEPH patients enrolled. Similar improvements in treatment-naive patients and patients found on an endothelin receptor antagonist at baseline. Drug-related crimet exerted significant effects on pulmonary hemodynamics, echocardiographic parameters , and N-terminal prohormone brain natriuretic peptide levels. Improvements in the in the World Health Organization functional class and Borg dyspnea score. The study also showed that riociguat was generally well tolerated. Three patients discontinued riociguat because of adverse events. Only encountered a serious adverse event was, as drug-related crime. This was the case of a patient, pulmonary edema, pulmonary venous presumably on the unmasking occlusive disease relative to be developed. There was no evidence of drug-induced changes in the laboratory parameters.

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